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Article
Expression Analysis of HIF-1a and HIF-2a genes in Tibetan Chicken under Normoxia and Hypoxia.pdf
Journal of Animal and Veterinary Advances (2011)
  • Yunzhou Yang, China Agricultural University
  • Ying Bai, China Agricultural University
  • Xinxing Dong, China Agricultural University
  • Jibin Zhang, China Agricultural University
  • Meiying Fang, China Agricultrual University
Abstract
Tibetan chicken is one of those chicken breeds that could adapt to high altitude and low oxygen pressure environment; it owes to an integrative genetic mechanism for hypoxia adaptability compared to lowland chicken breeds. HIF-1α and HIF-2α are the central factors playing important roles in maintaining organisms’s oxygen homeostasis. In this study, the expression of HIF-1α and HIF-2α genes were investigated by Real Time-PCR in Tibetan chicken and Dwarf chicken embryo brain tissue under normoxia (21% oxygen concentration) and hypoxia (13% oxygen concentration). The results showed that Tibetan chicken always had lower mortality than Dwarf chicken during the incubation. We also detected higher HIF-αs expression at the late of incubation (18th day) compared with that at 12th day in all tested samples; we further found that the expression pattern of HIF-αs genes in dead embryos was opposite to that in live embryos.
Keywords
  • Tibetan Chicken,
  • HIF-1alpha,
  • HIF-2alpha,
  • normoxia,
  • hypoxia,
  • adaptability
Publication Date
Winter December 1, 2011
DOI
http://dx.doi.org/10.3923/javaa.2011.2172.2175
Citation Information
Yunzhou Yang, Ying Bai, Xinxing Dong, Jibin Zhang, et al.. "Expression Analysis of HIF-1a and HIF-2a genes in Tibetan Chicken under Normoxia and Hypoxia.pdf" Journal of Animal and Veterinary Advances Vol. 10 Iss. 16 (2011) p. 2172 - 2175 ISSN: 1680-5593
Available at: http://works.bepress.com/jibin-zhang/5/