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Ouabain-induced Endocytosis and Signal Transduction of the Na/K-ATPase
Pharmaceutical Science and Research
  • Jiang Liu, Marshall University
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Na/K-ATPase can function as a signal transducer as well as an energy transducing ion pump. Cardiac glycosides (including ouabain and marinobufagin, MBG) are a new class of steroid hormones. Ouabain-activated signaling pathways lead to the induction of some early response proto-oncogenes, activation of transcription factors, and cardiac hypertrophy. Low concentration of ouabain also induced endocytosis of the Na/K-ATPase and compartmentalization of some signaling molecules (e.g. c-Src, EGFR, and p42/44 MAPKs) into clathrin-coated pits, early and late endosomes. Ouabain-induced endocytosis of the Na/K-ATPase depends on the activation of Src kinase, clathrin-coated pits formation, and caveolin-1 (the major component of caveolae). Moreover, low concentration ouabain significantly reduced transcellular Na+ transport. The data also show a srtonge interplay of ouabain-induced endocytosis of the Na/K-ATPase and signaling transduction.

The version of record is available from the publisher at Copyright © 2005 Frontiers in Bioscience. All rights reserved.

Citation Information
Liu, J. (2005). Ouabain-induced endocytosis and signal transduction of the Na/K-ATPase. Frontiers in Bioscience, 10, 2056-2063.