This paper presents an in-process inspection-oriented autonomously generative CMM (Coordinate Measuring Machine) part programming methodology with a simplified part programming process to decrease the time and skill for CMM part programming. The proposed method differs from the CAD-based CMM programming approach. Using this new method, machining features in a complex part can be efficiently inspected after any stage of machining operations or after machining these features. The concept of the proposed CMM part programming approach and its implementation are described in this paper. The results obtained from the feasibility study show the developed CMM part programming system can autonomously generate an inspection plan for a work-in-progress part model generated from NC programs to realize the in-process measurement.