Re-engineering the support layers of membranes for forward and pressure retarded osmosis is critical for making these technologies commercially viable. Real-world applications of forward and pressure retarded osmosis, especially those involving natural and waste waters, will require membranes to withstand significant stresses. Therefore, structural changes to the support layer, which are necessary in minimizing internal concentration polarization, must not compromise its critical abilities to resist mechanical stress and provide a suitable surface for the interfacial polymerization of a robust and selective active layer. Electrospinning can provide nanofibers for support layers to potentially overcome the limitations of traditional membrane fabrication techniques in fulfilling these challenging design criteria. In this work, we present the fabrication and evaluation of thin-film composite membranes composed of electrospun polyethylene terephthalate nanofibers, a phase separation formed microporous polysulfone layer, and a polyamide selective layer formed by interfacial polymerization. These membranes have active and support layer transport properties that are suitable for engineered osmosis, with water permeability of 1.13 L m− 2 h− 1 bar− 1 (3.14 × 10− 7 m s− 1 bar− 1), salt permeability of 0.23 L m− 2 h− 1 (6.4 × 10− 8 m s− 1), and a structural parameter of 651 μm. Relevant and easily reproducible tests for membrane resistance to mechanical stress were performed. The use of electrospun fibers in the support layer enhanced membrane resistance to delamination at high cross-flow velocities because the 340 nm diameter electrospun fibers enmesh with the microporous polysulfone layer. A broader discussion of the most promising approaches for using electrospun materials to improve membranes for engineered osmosis is provided.