The article presents a study which investigates drug usage among Hispanic men who have sex with men (HMSM) in South Florida. The study used 2 subscales of Behavioral Acculturation Scale, audio-computer assisted self-interview (ACASI) and multivariate analysis. The 566 HMSM respondents were recruited through the internet and community venues. The results show that the respondents have 43% of drug use and 45% unprotected anal sex. It reveals that drug use was linked with HIV seropositiviy, stronger gay community attachment, higher numbers of sex partners and lower homophobia levels. Proyecto Safer Options for Life (SOL), a theoretically grounded intervention that allows respondents to determine how culture and relationships influence HIV risk behaviors, is discussed..