In 2009, Kansas State University Libraries (K-State Libraries) moved from subject-based departments to user-based departments. From this change, subject matrices, including the Agriculture and Biological Science Matrix, were developed to address subject-related issues. This matrix is comprised of librarians from many K-State Libraries’ departments and is a conduit for sharing information interdepartmentally and developing collaborative opportunities. Libraries wishing to maintain a traditional subject-liaison model can adapt key principles underlying the matrix. Subject liaisons can go beyond siloed perspectives by soliciting advice from individuals outside the library. Another approach is to disturb established structures and introduce selective pressure to inspire innovation.