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Ultrasonographic observation of secretin-induced pancreatic duct dilation in healthy cats
Veterinary radiology & ultrasound : the official journal of the American College of Veterinary Radiology and the International Veterinary Radiology Association (2010)
  • Matthew L Baron, University of Tennessee - Knoxville
  • Silke Hecht, University of Tennessee - Knoxville
  • Andrea R Matthews, University of Tennessee - Knoxville
  • Jennifer E Stokes, University of Tennessee - Knoxville
Abstract
Secretin is a polypeptide hormone that stimulates secretion of bicarbonate from the exocrine pancreas and, in healthy human subjects, causes transient pancreatic duct dilation observable sonographically. In humans with chronic pancreatitis, secretin administration fails to cause pancreatic duct dilation, theoretically due to the restrictive effects of periductal fibrosis. We characterized the effect of exogenous secretin administration on the width of the pancreatic duct in nine healthy domestic cats. Cats were given a commercially available secretin product (ChiRho Stim) while the pancreatic duct was monitored sonographically. Mean pancreatic duct diameter increased from 0.77 +/- 0.33 to 1.42 +/- 0.40 mm after secretin administration (P = 0.0017). The mean percent increase in pancreatic duct diameter over basal diameter for all time points up to 15 min postsecretin administration was 101.9 +/- 58.8%. Applicability of this technique to diagnose chronic pancreatitis in cats will need to be investigated.
Disciplines
Publication Date
January, 2010
Citation Information
Matthew L Baron, Silke Hecht, Andrea R Matthews and Jennifer E Stokes. "Ultrasonographic observation of secretin-induced pancreatic duct dilation in healthy cats" Veterinary radiology & ultrasound : the official journal of the American College of Veterinary Radiology and the International Veterinary Radiology Association Vol. 51 Iss. 1 (2010)
Available at: http://works.bepress.com/jennifer_stokes/1/