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Article
Prognostic Significance of the Proliferation Index in Surgically-Resected Non-Small Cell Lung Cancer
Surgery
  • Jeffrey C. Pence, Wright State University
  • Billie-Jo M. Kerns
  • Richard K. Dodge
  • James Dirk Iglehart
Document Type
Article
Publication Date
12-1-1993
Abstract

Objective: To determine the utility of measuring the tumor proliferation index as a prognostic marker in patients with non—small-cell lung cancer.

Design: Immunostaining for the proliferationassociated antigen Ki-67, quantitated using computerassisted image cytometry, was used to derive the tumor proliferation index for 61 fresh-frozen, banked specimens of non—small-cell lung cancer. DNA ploidy was measured concomitantly for all specimens. A median follow-up of 38 months was achieved for survival analyses.

Setting: A large southeastern United States private referral institution and affiliated hospital provided the study environment.

Participants: A consecutive, convenience sample of 61 patients was enrolled based on resected tissue preservation and viability over a five-year accruement.

Main Outcome Measures: Significant associations between DNA content, proliferation index, established clinicopathological parameters, and outcome were examined.

Results: A significant inverse association between patient survival and tumor proliferation index was found that was independent of other established clinicopathological predictors of outcome. Patients whose tumors harbored a proliferation index of less than 3.5 survived significantly longer than patients with tumors demonstrating higher values. No association between DNA content and proliferation index was uncovered.

Conclusion: Measurement of the proliferation index, as derived from quantitative Ki-67 immunostaining and analyzed by image cytometry, may provide significant complementary, if not independent, prognostic information for patients with non—small-cell lung cancer.

DOI
10.1001/archsurg.1993.01420240090017
Citation Information
Jeffrey C. Pence, Billie-Jo M. Kerns, Richard K. Dodge and James Dirk Iglehart. "Prognostic Significance of the Proliferation Index in Surgically-Resected Non-Small Cell Lung Cancer" Surgery Vol. 128 Iss. 12 (1993) p. 1382 - 1390 ISSN: 00040010
Available at: http://works.bepress.com/jeffrey_pence/19/