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Article
Are Analogue Insulins Superior to Human Insulin in Clinical Practice?
Current Diabetes Reports
  • Jeffrey S. Freeman, Philadelphia College of Osteopathic Medicine
Document Type
Article
Publication Date
6-1-2010
Abstract
Insulin analogues were designed to provide more physiologic pharmacokinetic and pharmacodynamic properties compared with human insulin. This article examines the literature over a 2-year period, focusing on studies directly comparing analogue and human insulin in controlled clinical trials and large observational studies documenting the introduction of, or change to, analogue insulin in clinical practice. Findings indicate that analogues provide objective benefits that include improved glycemic control, lower risk of hypoglycemia, lower glucose variability, and (for insulin detemir) reduced weight gain. Recent data with analogues also explore their safety and efficacy in special patient groups such as children and adolescents. These data complement increasing evidence that analogues offer improved acceptability and accessibility to people with diabetes.
PubMed ID
20425580
Comments

This article was published in Current Diabetes Reports, Volume 10, Issue 3, June 2010, Pages 176-83.

The published version is available at http://dx.doi.org/10.1007/s11892-010-0104-8

Copyright © 2010 Springer, Part of Springer Science+Business Media

Citation Information
Jeffrey S. Freeman. "Are Analogue Insulins Superior to Human Insulin in Clinical Practice?" Current Diabetes Reports Vol. 10 Iss. 3 (2010) p. 176 - 183
Available at: http://works.bepress.com/jeffrey_freeman/3/