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Effects of Recent Concussion on Brain Bioenergetics: A Phosphorus-31 Magnetic Resonance Spectroscopy Study
University of Massachusetts Medical School Faculty Publications
  • Elif M. Sikoglu, University of Massachusetts Medical School
  • Ana A. Liso Navarro, University of Massachusetts Medical School
  • Suzanne M. Czerniak, University of Massachusetts Medical School
  • Joseph McCafferty, University of Massachusetts Medical School
  • Jordan Eisenstock, University of Massachusetts Medical School
  • J. Herbert Stevenson, University of Massachusetts Medical School
  • Jean A. King, University of Massachusetts Medical School
  • Constance M. Moore, University of Massachusetts Medical School
UMMS Affiliation
Department of Psychiatry; Department of Neurology
Publication Date
12-1-2015
Document Type
Article
Abstract
BACKGROUND: Although clinical evaluations and neurocognitive assessments are commonly used to evaluate the extent of and recovery from concussion, brain bioenergetics could provide a more quantitative marker. The neurometabolic response to a concussion is thought to increase neuronal energy consumption and thus the demand for nucleoside triphosphate (NTP). OBJECTIVE: We investigated the possible disruption in high-energy metabolism within the prefrontal cortex of college athletes who had either had a concussion within the past 6 months (n=14) or had never had a concussion (n=13). We hypothesized that concussed athletes would have imbalanced brain bioenergetics resulting from increased NTP consumption, and these biochemical changes would correspond to impaired cognitive abilities. METHODS: We used phosphorus-31 magnetic resonance spectroscopy to quantify high-energy phosphates. We performed the neuroimaging in conjunction with neurocognitive assessments targeting prefrontal cortex-mediated tasks. RESULTS: Our results revealed significantly lower gamma-NTP levels in the athletes after concussion. Although the concussed and non-concussed participants performed similarly in neurocognitive assessments, lower levels of gamma-NTP were associated with worse scores on neurocognitive tasks. CONCLUSIONS: Our results support the concept of increased energy demand in the prefrontal cortex of a concussed brain, and we found that while neurocognitive assessments appear normal, brain energetics may be abnormal. A longitudinal study could help establish brain NTP levels as a biomarker to aid in diagnosis and to assess recovery in concussed patients.
Rights and Permissions
Citation: Cogn Behav Neurol. 2015 Dec;28(4):181-7. doi: 10.1097/WNN.0000000000000076. Link to article on publisher's site
Related Resources
Link to Article in PubMed
PubMed ID
26705264
Citation Information
Elif M. Sikoglu, Ana A. Liso Navarro, Suzanne M. Czerniak, Joseph McCafferty, et al.. "Effects of Recent Concussion on Brain Bioenergetics: A Phosphorus-31 Magnetic Resonance Spectroscopy Study" Vol. 28 Iss. 4 (2015) ISSN: 1543-3633 (Linking)
Available at: http://works.bepress.com/jean_king/78/