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Keeping Weight Off: study protocol of an RCT to investigate brain changes associated with mindfulness-based stress reduction
Open Access Articles
  • Carl E. Fulwiler, University of Massachusetts Medical School
  • Julia A. Siegel, University of Massachusetts Medical School
  • Jeroan J. Allison, University of Massachusetts Medical School
  • Milagros C. Rosal, University of Massachusetts Medical School
  • Judson A. Brewer, University of Massachusetts Medical School
  • Jean A. King, University of Massachusetts Medical School
UMMS Affiliation
Department of Psychiatry; Center for Mindfulness; Department of Medicine, Division of Preventive and Behavioral Medicine; Department of Quantitative Health Sciences; School of Medicine
Date
11-30-2016
Document Type
Article
Abstract
INTRODUCTION: Obesity is a growing epidemic fuelled by unhealthy behaviours and associated with significant comorbidities and financial costs. While behavioural interventions produce clinically meaningful weight loss, weight loss maintenance is challenging. This may partially be due to failure to target stress and emotional reactivity. Mindfulness-based stress reduction (MBSR) reduces stress and emotional reactivity and may be a useful tool for behaviour change maintenance. This study seeks to provide a mechanistic understanding for clinical trials of the benefits of MBSR for weight loss maintenance by examining changes in functional connectivity (FC) and the association of these changes with clinical outcomes. METHODS AND ANALYSIS: Community-dwelling individuals (n=80) who intentionally lost > /=5% of their body weight in the past year will be recruited and randomised to an MBSR programme or educational control. FC using resting-state functional MRI will be measured at baseline and 8 weeks. Psychological factors, health behaviours, body mass index and waist circumference will be measured at baseline, 8 weeks and 6 months post intervention. A 12-month telephone follow-up will assess self-reported weight. Analyses will characterise FC changes in response to MBSR in comparison with a control condition, assess the relationship between baseline FC status and pre-post MBSR changes in FC and investigate the association of FC change with changes in psychological factors and weight loss maintenance. ETHICS AND DISSEMINATION: The University of Massachusetts Medical School Institutional Review Board has approved this study, Declaration of Helsinki protocols are being followed, and patients will give written informed consent. The Independent Monitoring Committee will monitor protocol adherence. Results from the study will be disseminated to the medical community at conferences and submitted for publication in peer-reviewed journals when the last patient included has been followed up for 12 months. TRIAL REGISTRATION NUMBER: NCT02189187.
Rights and Permissions
Citation: BMJ Open. 2016 Nov 30;6(11):e012573. doi: 10.1136/bmjopen-2016-012573. Link to article on publisher's site
Comments

Co-author Julia Siegel is a medical student at UMass Medical School.

Related Resources
Link to Article in PubMed
Keywords
  • behavior change maintenance,
  • mindfulness,
  • neuroimaging,
  • weight loss
PubMed ID
27903561
Creative Commons License
Creative Commons Attribution-Noncommercial 4.0
Citation Information
Carl E. Fulwiler, Julia A. Siegel, Jeroan J. Allison, Milagros C. Rosal, et al.. "Keeping Weight Off: study protocol of an RCT to investigate brain changes associated with mindfulness-based stress reduction" Vol. 6 Iss. 11 (2016) ISSN: 2044-6055 (Linking)
Available at: http://works.bepress.com/jean_king/76/