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Article
Nicotine and Resting-State Functional Connectivity: Effects of Intermittent Doses
University of Massachusetts Medical School Faculty Publications
  • Wei Huang, University of Massachusetts Medical School
  • Kelly Tam, University of Massachusetts Medical School
  • Janaque Fernando, University of Massachuetts Medical School
  • Meghan E. Heffernan, University of Massachusetts Medical School
  • Jean A. King, University of Massachusetts Medical School
  • Joseph R. DiFranza, University of Massachusetts Medical School
UMMS Affiliation
Department of Psychiatry, Center for Comparative NeuroImaging; Department of Family Medicine and Community Health
Date
11-1-2015
Document Type
Article
Abstract

INTRODUCTION: It is unknown how the timing between doses might affect nicotine's impact on neural activity. Our objective was to examine how the interdose interval affects nicotine's impact on resting-state functional connectivity (rsFC).

MATERIALS AND METHODS: Adult male Sprague-Dawley rats were administered nicotine daily (0.4 mg/kg) over 6 days while control animals received saline vehicle. Functional magnetic resonance imaging was used to measure rsFC before and after a challenge dose of nicotine (0.4 mg/kg) delivered for the first time and 3, 6, 12, or 24hr after the previous dose.

RESULTS: As the interval between nicotine doses increased from 3 to 24hr, the strength of rsFC increased in some circuits, particularly the nucleus accumbens and prefrontal circuits, and decreased in others, namely the interpeduncular nucleus, hippocampus, caudoputamen, retrosplenial cortex, ventral tegmental, and the insular circuits.

CONCLUSIONS: These data indicate that the effect that nicotine has on the brain is affected by the amount of time that has passed since the previous dose. The effect on rsFC of cumulative doses is not additive. This may have important implications for the study of nicotine addiction as it implies that the same dose of nicotine might have a different impact on the brain depending on the time elapsed from the previous exposure.

Rights and Permissions
Citation: Nicotine Tob Res. 2015 Nov;17(11):1311-7. doi: 10.1093/ntr/ntv009. Epub 2015 Feb 2. Link to article on publisher's site
Related Resources
Link to Article in PubMed
PubMed ID
25646348
Citation Information
Wei Huang, Kelly Tam, Janaque Fernando, Meghan E. Heffernan, et al.. "Nicotine and Resting-State Functional Connectivity: Effects of Intermittent Doses" Vol. 17 Iss. 11 (2015) ISSN: 1462-2203 (Linking)
Available at: http://works.bepress.com/jean_king/71/