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A splitting brain: Imbalanced neural networks in schizophrenia
Systems and Psychosocial Advances Research Center Publications and Presentations
  • Mingli Li, Sichuan University
  • Wei Deng, Sichuan University
  • Zongling He, Sichuan University
  • Qiang Wang, Sichuan University
  • Chaohua Huang, Sichuan University
  • Lijun Jiang, Sichuan University
  • Qiyong Gong, Sichuan University
  • Douglas M. Ziedonis, University of Massachusetts Medical School
  • Jean A. King, University of Massachusetts Medical School
  • Xiaohong Ma, Sichuan University
  • Nanyin Zhang, University of Massachusetts Medical School
  • Tao Li, Sichuan University
UMMS Affiliation
Department of Psychiatry; Systems and Psychosocial Advances Research Center
Publication Date
Document Type
Adolescent; Adult; Brain; Brain Mapping; Female; Humans; Magnetic Resonance Imaging; Male; Nerve Net; Schizophrenia; Young Adult
Dysconnectivity between key brain systems has been hypothesized to underlie the pathophysiology of schizophrenia. The present study examined the pattern of functional dysconnectivity across whole-brain neural networks in 121 first-episode, treatment-naive patients with schizophrenia by using resting-state functional magnetic resonance imaging (rsfMRI). Group independent component analysis (ICA) was first applied to rsfMRI data to extract 90 functional components of the brain. The functional connectivity between these ICA components was then evaluated and compared between the patient and control groups. To examine the functional roles of significantly altered between-component connections in patients, each ICA component was ascribed to one of 10 previously well-defined brain networks/areas. Relative to findings in healthy controls (n=103), 29 altered functional connections including 19 connections with increased connectivity and 10 connections with decreased connectivity in schizophrenia patients were found. Increased connectivity was mainly within the default mode network (DMN) and between the DMN and cognitive networks, whereas decreased connectivity was predominantly associated with sensory networks. Given the key roles of the DMN in internal mental processes and sensory networks in inputs from the external environment, these patterns of altered brain network connectivity could suggest imbalanced neural processing of internal and external information in schizophrenia.
  • Functional connectivity,
  • Neural networks,
  • Resting state,
  • Schizophrenia,
  • fMRI
DOI of Published Version
Psychiatry Res. 2015 May 30;232(2):145-53. doi: 10.1016/j.pscychresns.2015.03.001. Epub 2015 Mar 11. Link to article on publisher's site
Related Resources
Link to Article in PubMed
PubMed ID
Citation Information
Mingli Li, Wei Deng, Zongling He, Qiang Wang, et al.. "A splitting brain: Imbalanced neural networks in schizophrenia" Vol. 232 Iss. 2 (2015) ISSN: 0165-1781 (Linking)
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