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Article
A dual RF resonator system for high-field functional magnetic resonance imaging of small animals
Psychiatry Publications and Presentations
  • Reinhold Ludwig, Worcester Polytechnic Institute
  • G. Bodgdanov, Worcester Polytechnic Institute
  • Jean A. King, University of Massachusetts Medical School
  • A. Allard, University of Massachusetts Medical Center
  • Craig F. Ferris, University of Massachusetts Medical School
UMMS Affiliation
Department of Psychiatry
Date
1-7-2004
Document Type
Article
Medical Subject Headings
Animals; Brain; Brain Mapping; Electromagnetic Fields; Electronics; Electrophysiology; Magnetic Resonance Imaging; Magnetics; Neurophysiology; Rats; Reproducibility of Results; Restraint, Physical; Sensitivity and Specificity
Disciplines
Abstract
A new apparatus has been developed that integrates an animal restrainer arrangement for small animals with an actively tunable/detunable dual radio-frequency (RF) coil system for in vivo anatomical and functional magnetic resonance imaging of small animals at 4.7 T. The radio-frequency coil features an eight-element microstrip line configuration that, in conjunction with a segmented outer copper shield, forms a transversal electromagnetic (TEM) resonator structure. Matching and active tuning/detuning is achieved through fixed/variable capacitors and a PIN diode for each resonator element. These components along with radio-frequency chokes (RFCs) and blocking capacitors are placed on two printed circuit boards (PCBs) whose copper coated ground planes form the front and back of the volume coil and are therefore an integral part of the resonator structure. The magnetic resonance signal response is received with a dome-shaped single-loop surface coil that can be height-adjustable with respect to the animal's head. The conscious animal is immobilized through a mechanical arrangement that consists of a Plexiglas body tube and a head restrainer. This restrainer has a cylindrical holder with a mouthpiece and position screws to receive and restrain the head of the animal. The apparatus is intended to perform anatomical and functional magnetic resonance imaging in conscious animals such as mice, rats, hamsters, and marmosets. Cranial images acquired from fully conscious rats in a 4.7 T Bruker 40 cm bore animal scanner underscore the feasibility of this approach and bode well to extend this system to the imaging of other animals.
Rights and Permissions
Citation: J Neurosci Methods. 2004 Jan 30;132(2):125-35.
Related Resources
Link to Article in PubMed
PubMed ID
14706710
Citation Information
Reinhold Ludwig, G. Bodgdanov, Jean A. King, A. Allard, et al.. "A dual RF resonator system for high-field functional magnetic resonance imaging of small animals" Vol. 132 Iss. 2 (2004) ISSN: 0165-0270 (Linking)
Available at: http://works.bepress.com/jean_king/16/