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Article
Mapping resting-state brain networks in conscious animals
Psychiatry Publications and Presentations
  • Nanyin Zhang, University of Massachusetts Medical School
  • Pallavi Rane, University of Massachusetts Medical School
  • Wei Huang, University of Massachusetts Medical School
  • Zhifeng Liang, University of Massachusetts Medical School
  • David Kennedy, University of Massachusetts Medical School
  • Jean A. Frazier, University of Massachusetts Medical School
  • Jean A. King, University of Massachusetts Medical School
UMMS Affiliation
Department of Psychiatry
Date
4-13-2010
Document Type
Article
Medical Subject Headings
Animals; Brain; Brain Mapping; Cerebral Cortex; Cerebrovascular Circulation; Consciousness; Feasibility Studies; Imaging, Three-Dimensional; Magnetic Resonance Imaging; Male; Neural Pathways; Oxygen; Prefrontal Cortex; Rats; Rats, Long-Evans; Reproducibility of Results; Rest; Signal Processing, Computer-Assisted; Thalamus; Wakefulness
Disciplines
Abstract
In the present study we mapped brain functional connectivity in the conscious rat at the "resting state" based on intrinsic blood-oxygenation-level dependent (BOLD) fluctuations. The conscious condition eliminated potential confounding effects of anesthetic agents on the connectivity between brain regions. Indeed, using correlational analysis we identified multiple cortical and subcortical regions that demonstrated temporally synchronous variation with anatomically well-defined regions that are crucial to cognitive and emotional information processing including the prefrontal cortex (PFC), thalamus and retrosplenial cortex. The functional connectivity maps created were stringently validated by controlling for false positive detection of correlation, the physiologic basis of the signal source, as well as quantitatively evaluating the reproducibility of maps. Taken together, the present study has demonstrated the feasibility of assessing functional connectivity in conscious animals using fMRI and thus provided a convenient and non-invasive tool to systematically investigate the connectional architecture of selected brain networks in multiple animal models.
Rights and Permissions
Citation: J Neurosci Methods. 2010 Jun 15;189(2):186-96. Epub 2010 Apr 9. Link to article on publisher's site
Related Resources
Link to Article in PubMed
PubMed ID
20382183
Citation Information
Nanyin Zhang, Pallavi Rane, Wei Huang, Zhifeng Liang, et al.. "Mapping resting-state brain networks in conscious animals" Vol. 189 Iss. 2 (2010) ISSN: 0165-0270 (Linking)
Available at: http://works.bepress.com/jean_frazier/63/