Skip to main content
Donepezil in the treatment of ADHD-like symptoms in youths with pervasive developmental disorder: a case series
Psychiatry Publications and Presentations
  • Robert L. Doyle, Harvard Medical School
  • Jean A. Frazier, University of Massachusetts Medical School
  • Thomas J. Spencer, Harvard Medical School
  • Daniel A. Geller, Harvard Medical School
  • Joseph Biederman, Harvard Medical School
  • Timothy E. Wilens, Harvard Medical School
UMMS Affiliation
Department of Psychiatry
Publication Date
Document Type
Adolescent; Attention Deficit Disorder with Hyperactivity; Child; Child Development Disorders, Pervasive; Cholinesterase Inhibitors; Communication; Drug Administration Schedule; Female; Humans; Indans; Male; Piperidines; Social Behavior
BACKGROUND: Recent studies reported ADHD-like symptoms and cognitive deficits in pervasive developmental disorder (PDD). Because work in dementia documents improvement in executive function deficits with the acetylcholinesterase inhibitor donepezil, the authors reason that similar benefits could be obtained in PDD. METHOD: The authors describe eight cases of PDD youth ages 10 to 17 treated with donepezil targeting ADHD-like symptoms associated with PDD. RESULTS: Most participants improve ADHD-like symptomatology. In addition, improvement in communication and socialization is noted. CONCLUSION: Donepezil may have a role in treating ADHD-like symptoms in children with PDD.
DOI of Published Version
J Atten Disord. 2006 Feb;9(3):543-9. Link to article on publisher's site
Related Resources
Link to Article in PubMed
PubMed ID
Citation Information
Robert L. Doyle, Jean A. Frazier, Thomas J. Spencer, Daniel A. Geller, et al.. "Donepezil in the treatment of ADHD-like symptoms in youths with pervasive developmental disorder: a case series" Vol. 9 Iss. 3 (2006) ISSN: 1087-0547 (Linking)
Available at: