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Neurocognition in early-onset schizophrenia and schizoaffective disorders
Psychiatry Publications and Presentations
  • Stephen R. Hooper, University of North Carolina
  • Anthony J. Giuliano, Harvard Medical School
  • Eric A. Youngstrom, University of North Carolina
  • David Breiger, University of Washington
  • Linmarie Sikich, University of North Carolina
  • Jean A. Frazier, University of Massachusetts Medical School
  • Robert L. Findling, Case Western Reserve University
  • Jon McClellan, University of Washington
  • Robert M. Hamer, University of North Carolina
  • Benedetto Vitiello, National Institute of Mental Health
  • Jeffrey A. Lieberman, University of North Carolina
UMMS Affiliation
Department of Psychiatry
Publication Date
Document Type
Achievement; Adolescent; Child; Cognition Disorders; Female; Humans; Intelligence; Male; *Neuropsychological Tests; Psychiatric Status Rating Scales; Psychometrics; Psychotic Disorders; Schizophrenia; *Schizophrenic Psychology
OBJECTIVE: We examined the neuropsychological functioning of youth enrolled in the NIMH funded trial, Treatment of Early-Onset Schizophrenia Spectrum Disorders (TEOSS). We compared the baseline neuropsychological functioning of youth with schizophrenia (SZ, n = 79) to those with schizoaffective disorder (SA, n = 40), and examined the relationship of different variables of illness severity and adaptive behavior to neuropsychological functioning. METHOD: Participants ranged in age from 8 to 19 years. Diagnostic status was confirmed via structured interview over multiple time points. Domains of neuropsychological functioning included fine-motor, attention, working memory, problem-solving efficiency, inhibitory control, and social cognition. Other variables included intelligence (IQ), academic achievement skills, adaptive behavior, and different measures of illness severity. RESULTS: The two groups did not differ on IQ or on any of the neuropsychological domains. The SZ group performed significantly lower in spelling. A high proportion of individuals in both groups reflected significant intellectual and academic achievement skill deficits. Significant correlations were found between the neurocognitive domains and both illness severity and adaptive behavior variables. CONCLUSIONS: There were few differences between the SZ and SA groups on IQ, achievement, or neuropsychological functioning; however, both groups showed significantly high rates of deficits in IQ and basic academic skills. Correlations of the neurocognitive functions with illness severity and adaptive behavior were small to moderate in magnitude. These findings continue to implicate the importance of neurocognitive functioning as a key area of vulnerability in the study of youth with schizophrenia spectrum disorders.
DOI of Published Version
J Am Acad Child Adolesc Psychiatry. 2010 Jan;49(1):52-60. Link to article on publisher's website
Related Resources
Link to Article in PubMed
PubMed ID
Citation Information
Stephen R. Hooper, Anthony J. Giuliano, Eric A. Youngstrom, David Breiger, et al.. "Neurocognition in early-onset schizophrenia and schizoaffective disorders" Vol. 49 Iss. 1 (2010) ISSN: 0890-8567 (Linking)
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