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Childhood-onset schizophrenia: brain MRI rescan after 2 years of clozapine maintenance treatment
Psychiatry Publications and Presentations
  • Jean A. Frazier, University of Massachusetts Medical School
  • Jay N. Giedd, University of Maryland School of Medicine
  • Debra Kaysen, Northwestern University School of Medicine
  • K. E. Albus, National Institutes of Health
  • Susan D. Hamburger, National Institute of Mental Health
  • Javad Alaghband-Rad, National Institute of Mental Health
  • Marge C. Lenane, National Institute of Mental Health, Bethesda, MD
  • Kathleen McKenna, National Institute of Mental Health
  • Alan Breier, University of Indiana
  • Judith L. Rapoport, National Institute of Mental Health
UMMS Affiliation
Department of Psychiatry
Publication Date
Document Type
Adolescent; Age of Onset; Antipsychotic Agents; Basal Ganglia; Brain; Caudate Nucleus; Cerebral Ventricles; Child; Clozapine; Female; Follow-Up Studies; Humans; *Magnetic Resonance Imaging; Male; Putamen; Schizophrenia, Childhood

OBJECTIVE: The effect of clozapine on striatal morphology was examined in adolescents with childhood-onset schizophrenia.

METHOD: Eight adolescent patients with onset of psychosis before age 12 and eight matched comparison subjects had initial and 2-year follow-up brain magnetic resonance imaging scans. Basal ganglia and lateral ventricle volumes were measured. The patients were on a clozapine regimen during the 2-year interim.

RESULTS: Caudate volume was larger in the patients at the initial scanning, decreased in the patients between scans, and did not differ significantly between the patients and the comparison subjects at the second scanning.

CONCLUSIONS: Caudate enlargement in patients with childhood-onset schizophrenia who are taking typical neuroleptics appears to be secondary to medication exposure. Rescanning to examine basal ganglia morphology is indicated for these patients when they are taking an atypical neuroleptic.

Am J Psychiatry. 1996 Apr;153(4):564-6.
Related Resources
Link to Article in PubMed
PubMed ID
Citation Information
Jean A. Frazier, Jay N. Giedd, Debra Kaysen, K. E. Albus, et al.. "Childhood-onset schizophrenia: brain MRI rescan after 2 years of clozapine maintenance treatment" Vol. 153 Iss. 4 (1996) ISSN: 0002-953X (Linking)
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