Skip to main content
Article
An open trial of clozapine in 11 adolescents with childhood-onset schizophrenia
Psychiatry Publications and Presentations
  • Jean A. Frazier, University of Massachusetts Medical School
  • Charles T. Gordon, National Institute of Mental Health
  • Kathleen McKenna, National Institute of Mental Health
  • Marge C. Lenane, National Institute of Mental Health
  • Debbie Jih, National Institute of Mental Health
  • Judith L. Rapoport, National Institute of Mental Health
UMMS Affiliation
Department of Psychiatry
Date
6-1-1994
Document Type
Article
Medical Subject Headings
Adolescent; Child; Clozapine; Double-Blind Method; Female; Haloperidol; Humans; Male; Psychiatric Status Rating Scales; Schizophrenia, Childhood
Disciplines
Abstract

OBJECTIVE: To review the response of 11 adolescents with childhood-onset schizophrenia to a 6-week open clozapine trial.

METHOD: Eleven children meeting DSM-III-R criteria for schizophrenia had a 6-week open trial of clozapine (mean sixth week daily dose 370 mg). Behavioral ratings included the Brief Psychiatric Rating Scale and Children's Global Assessment Scale.

RESULTS: More than half showed marked improvement in Brief Psychiatric Rating Scale ratings by 6 weeks of clozapine therapy compared to admission drug rating and compared to a systematic 6-week trial of haloperidol.

CONCLUSIONS: This open trial indicates that clozapine may be a promising treatment for children and adolescents with schizophrenia who do not respond well to typical neuroleptics. A double-blind placebo-controlled study is ongoing.

Rights and Permissions
Citation: J Am Acad Child Adolesc Psychiatry. 1994 Jun;33(5):658-63. Link to article on publisher's site
Related Resources
Link to Article in PubMed
PubMed ID
8056728
Citation Information
Jean A. Frazier, Charles T. Gordon, Kathleen McKenna, Marge C. Lenane, et al.. "An open trial of clozapine in 11 adolescents with childhood-onset schizophrenia" Vol. 33 Iss. 5 (1994) ISSN: 0890-8567 (Linking)
Available at: http://works.bepress.com/jean_frazier/41/