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Article
Brain anatomic magnetic resonance imaging in childhood-onset schizophrenia
Psychiatry Publications and Presentations
  • Jean A. Frazier, University of Massachusetts Medical School
  • Jay N. Giedd, University of Maryland School of Medicine
  • Susan D. Hamburger, National Institute of Mental Health
  • K. E. Albus, National Institutes of Health
  • Debra Kaysen, Northwestern University School of Medicine
  • A. Catherine Vaituzis, the University of Maryland School of Medicine
  • Jagath C. Rajapakse, University of Maryland School of Medicine
  • Marge C. Lenane, National Institute of Mental Health
  • Kathleen McKenna, National Institute of Mental Health
  • Leslie K. Jacobsen, University of Maryland School of Medicine
  • Charles T. Gordon, National Institute of Mental Health
  • Alan Breier, University of Indiana
  • Judith L. Rapoport, National Institute of Mental Health
UMMS Affiliation
Department of Psychiatry
Date
7-1-1996
Document Type
Article
Medical Subject Headings
Adolescent; Adult; Age of Onset; Brain; Caudate Nucleus; Cerebral Ventricles; Child; Globus Pallidus; Humans; *Magnetic Resonance Imaging; Putamen; Schizophrenia, Childhood; Thalamus
Disciplines
Abstract
BACKGROUND: Early-onset schizophrenia (first psychotic symptoms by age 12 years) has been the subject of a small number of studies, and its biological continuity with later-onset disorder has not been established. In this study quantitative anatomic brain magnetic resonance images of children and adolescents with early-onset schizophrenia were compared with those of matched controls. Brain abnormalities in childhood-onset schizophrenia were examined in relation to those reported for later-onset schizophrenics. METHODS: Anatomic brain magnetic resonance imaging scans were obtained for 21 patients (mean +/- SD age, 14.6 +/- 2.1 years; range, 10 to 18 years) with childhood-onset schizophrenia (13 males, eight females) and 33 age-, sex-, height-, and weight-matched normal controls. Quantitative measurements were obtained for the cerebrum, anterior frontal region, lateral ventricles, thalamus, caudate, putamen, and globus pallidus. RESULTS: Total cerebral volume and midsagittal thalamic area were smaller in the patients (analysis of variance, P = .002, and analysis of covariance, P = .03, respectively); the caudate, putamen, and globus pallidus were larger in the patients (analysis of covariance, P = .05, P = .007, and P < .001, respectively); and the lateral ventricles tended to be larger in the patients (analysis of covariance, P = .06). Globus pallidus enlargement correlated with neuroleptic exposure and with age of onset of psychosis. The magnitude of abnormalities compared with controls was similar to that reported in adult studies, although there was a trend toward relatively smaller cerebral volumes for the childhood-onset group compared with controls. CONCLUSION: Brain anatomic abnormalities in childhood-onset schizophrenia are similar to those reported for adult populations, indicating overall continuity between these rare childhood cases and the adult schizophrenia populations.
Rights and Permissions
Citation: Arch Gen Psychiatry. 1996 Jul;53(7):617-24.
Related Resources
Link to Article in PubMed
PubMed ID
8660128
Citation Information
Jean A. Frazier, Jay N. Giedd, Susan D. Hamburger, K. E. Albus, et al.. "Brain anatomic magnetic resonance imaging in childhood-onset schizophrenia" Vol. 53 Iss. 7 (1996) ISSN: 0003-990X (Linking)
Available at: http://works.bepress.com/jean_frazier/38/