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Temporal lobe morphology in childhood-onset schizophrenia
Psychiatry Publications and Presentations
  • Leslie K. Jacobsen, University of Maryland School of Medicine
  • Jay N. Giedd, University of Maryland School of Medicine
  • A. Catherine Vaituzis, the University of Maryland School of Medicine
  • Susan D. Hamburger, National Institute of Mental Health
  • Jagath C. Rajapakse, University of Maryland School of Medicine
  • Jean A. Frazier, University of Massachusetts Medical School
  • Debra Kaysen, Northwestern University School of Medicine
  • Marge C. Lenane, National Institute of Mental Health
  • Kathleen McKenna, National Institute of Mental Health
  • Charles T. Gordon, National Institute of Mental Health
  • Judith L. Rapoport, National Institute of Mental Health
UMMS Affiliation
Department of Psychiatry
Publication Date
Document Type
Adolescent; Age of Onset; Amygdala; Child; Female; Hippocampus; Humans; Magnetic Resonance Imaging; Male; Psychiatric Status Rating Scales; Schizophrenia; Schizophrenia, Childhood; *Schizophrenic Psychology; Sex Factors; Temporal Lobe
OBJECTIVE: Neurodevelopmental models of schizophrenia imply that a more severe early brain lesion may produce earlier onset of psychotic symptoms. The medial temporal lobes have been proposed as possible locations for such a lesion. The authors tested this hypothesis in a group of children and adolescents with childhood-onset schizophrenia who had severe, chronic symptoms and who were refractory to treatment with typical neuroleptics. METHOD: Anatomic brain magnetic resonance imaging scans were acquired with a 1.5-T scanner for 21 patients (mean age=14.6 years, SD=2.1) who had onset of schizophrenia by age 12 (mean age at onset=10.2, SD=1.5) and 41 normal children. Volumes of the temporal lobe, superior temporal gyrus, amygdala, and hippocampus were measured by manually outlining these structures on contiguous 2-mm thick coronal slices. RESULTS: Patients with childhood-onset schizophrenia had significantly smaller cerebral volumes. With no adjustment for brain volume, no diagnostic differences were observed for any temporal lobe structure. Unexpectedly, with adjustment for total cerebral volume, larger volumes of the superior temporal gyrus and its posterior segment and a trend toward larger temporal lobe volume emerged for the patients with schizophrenia. These patients lacked the normal (right-greater-than-left) hippocampal asymmetry. CONCLUSIONS: These findings do not indicate a more severe medial temporal lobe lesion as the basis of very early onset schizophrenia.
Am J Psychiatry. 1996 Mar;153(3):355-61.
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Link to Article in PubMed
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Citation Information
Leslie K. Jacobsen, Jay N. Giedd, A. Catherine Vaituzis, Susan D. Hamburger, et al.. "Temporal lobe morphology in childhood-onset schizophrenia" Vol. 153 Iss. 3 (1996) ISSN: 0002-953X (Linking)
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