Abnormal neurologic maturation in adolescents with early-onset schizophreniaPsychiatry Publications and Presentations
UMMS AffiliationDepartment of Psychiatry
Medical Subject HeadingsAdolescent; Adult; Age Factors; Age of Onset; Cohort Studies; Comorbidity; Female; Humans; Male; Nervous System Diseases; Neurologic Examination; Schizophrenia
AbstractOBJECTIVE: This study evaluated neurologic functioning in adolescents with schizophrenia with onset of psychosis before age 13. METHOD: The authors administered a structured neurologic examination to 21 adolescents with early-onset schizophrenia and 27 healthy age- and sex-matched comparison subjects. RESULTS: The adolescents with schizophrenia had a high frequency of neurologic abnormalities. Neurologic signs decreased with age in the healthy comparison subjects but not in the subjects with schizophrenia. CONCLUSIONS: The adolescents with schizophrenia had a high burden of neurologic impairment and a pattern of abnormalities similar to that of adults with schizophrenia. The persistence of neurologic signs in the adolescents with schizophrenia, which faded with age in the healthy comparison adolescents, supports earlier evidence of a delay in or failure of normal brain development during adolescence.
Rights and PermissionsCitation: Am J Psychiatry. 2001 Jan;158(1):118-22.
Related ResourcesLink to Article in PubMed
Citation InformationBarbara I. Karp, Marjorie Garvey, Leslie K. Jacobsen, Jean A. Frazier, et al.. "Abnormal neurologic maturation in adolescents with early-onset schizophrenia" Vol. 158 Iss. 1 (2001) ISSN: 0002-953X (Linking)
Available at: http://works.bepress.com/jean_frazier/14/