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Article
Abnormal neurologic maturation in adolescents with early-onset schizophrenia
Psychiatry Publications and Presentations
  • Barbara I. Karp, National Institute of Neurological Disorders and Stroke
  • Marjorie Garvey, National Institutes of Health
  • Leslie K. Jacobsen, University of Maryland School of Medicine
  • Jean A. Frazier, University of Massachusetts Medical School
  • Susan D. Hamburger, National Institute of Mental Health
  • Jeffrey S. Bedwell, National Institute of Mental Health
  • Judith L. Rapoport, National Institute of Mental Health
UMMS Affiliation
Department of Psychiatry
Date
1-4-2001
Document Type
Article
Medical Subject Headings
Adolescent; Adult; Age Factors; Age of Onset; Cohort Studies; Comorbidity; Female; Humans; Male; Nervous System Diseases; Neurologic Examination; Schizophrenia
Disciplines
Abstract
OBJECTIVE: This study evaluated neurologic functioning in adolescents with schizophrenia with onset of psychosis before age 13. METHOD: The authors administered a structured neurologic examination to 21 adolescents with early-onset schizophrenia and 27 healthy age- and sex-matched comparison subjects. RESULTS: The adolescents with schizophrenia had a high frequency of neurologic abnormalities. Neurologic signs decreased with age in the healthy comparison subjects but not in the subjects with schizophrenia. CONCLUSIONS: The adolescents with schizophrenia had a high burden of neurologic impairment and a pattern of abnormalities similar to that of adults with schizophrenia. The persistence of neurologic signs in the adolescents with schizophrenia, which faded with age in the healthy comparison adolescents, supports earlier evidence of a delay in or failure of normal brain development during adolescence.
Rights and Permissions
Citation: Am J Psychiatry. 2001 Jan;158(1):118-22.
Related Resources
Link to Article in PubMed
PubMed ID
11136643
Citation Information
Barbara I. Karp, Marjorie Garvey, Leslie K. Jacobsen, Jean A. Frazier, et al.. "Abnormal neurologic maturation in adolescents with early-onset schizophrenia" Vol. 158 Iss. 1 (2001) ISSN: 0002-953X (Linking)
Available at: http://works.bepress.com/jean_frazier/14/