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Selected Works of Jayce Sudweeks
Article
Genetic Analysis of Disease Subtypes and Sexual Dimorphisms in Mouse Experimental Allergic Encephalomyelitis (EAE): Relapsing/remitting and Monophasic Remitting/nonrelapsing EAE Are Immunogenetically Distinct
The Journal of Immunology (1999)
  • R. Butterfield
  • E. Blankenhorn
  • R. Roper
  • J. Zachary
  • R. Doerge
  • Jayce Sudweeks, Georgia Southern University
  • J. Rose
  • C. Teuscher
Link
Abstract
Experimental allergic encephalomyelitis (EAE) is the principal animal model of multiple sclerosis (MS), the major inflammatory disease of the central nervous system. Murine EAE is generally either an acute monophasic or relapsing disease. Because the clinical spectrum of MS is more diverse, the limited range of disease subtypes observed in EAE has raised concern regarding its relevance as a model for MS. During the generation of a large F2 mapping population between the EAE-susceptible SJL/J and EAE-resistant B10.S/DvTe inbred lines, we identified four distinct subtypes of murine EAE resembling clinical subtypes seen in MS. We observed acute progressive, chronic/nonremitting, remitting/relapsing, and monophasic remitting/nonrelapsing EAE. An additional subtype, benign EAE, was identified after histologic examination revealed that some mice had inflammatory infiltrates of the central nervous system, but did not show clinical signs of EAE. Genome exclusion mapping was performed to identify the loci controlling susceptibility to each disease subtype. We report three novel EAE-modifying loci on chromosomes 16, 7, and 13 (eae11-13, respectively). Additionally, unique loci with gender-specific effects govern susceptibility to remitting/relapsing (eae12) and monophasic remitting/nonrelapsing (eae7 and 13) EAE.
Keywords
  • Genetic analysis,
  • Disease subtypes,
  • Sexual dimorphisms,
  • Mouse experimental allergic encephalomyelitis,
  • EAE,
  • Relapsing/remitting,
  • Monophasic remitting/nonrelapsing,
  • Immunogenetically distinct
Disciplines
Publication Date
1999
Citation Information
R. Butterfield, E. Blankenhorn, R. Roper, J. Zachary, et al.. "Genetic Analysis of Disease Subtypes and Sexual Dimorphisms in Mouse Experimental Allergic Encephalomyelitis (EAE): Relapsing/remitting and Monophasic Remitting/nonrelapsing EAE Are Immunogenetically Distinct" The Journal of Immunology Vol. 162 Iss. 5 (1999) p. 3096 - 3102
Available at: http://works.bepress.com/jayce-sudweeks/3/