SelectedWorks - Jay Steingrub MD

Contact

Selected Works of Jay Steingrub MD

Vice-Chair of Research, Department of Medicine

Works
About

×

About Jay Steingrub MD

Present	Director, Medical Intensive Care Unit, Baystate Health
Institution Organization Position Type Position Title Time Period to Options Current Position Affiliate my profile with this Institution
Present	Professor of Medicine, Tufts University School of Medicine
Institution Organization Position Type Position Title Time Period to Options Current Position Affiliate my profile with this Institution
Present	Vice-Chair of Research, Department of Medicine, Baystate Health
Institution Organization Position Type Position Title Time Period to Options Current Position Affiliate my profile with this Institution

Medicine and Health Sciences

Baystate Education and Research

Baystate Critical Care Medicine
759 Chestnut Street
Springfield, MA 01199

Email:

Update to the study protocol for an implementation-effectiveness trial comparing two education strategies for improving the uptake of noninvasive ventilation in patients with severe COPD exacerbation (Mihaela Stefan, Penny Pekow, Jay Steingrub, et al.) All Scholarly Works (2021)

Background: There is strong evidence that noninvasive ventilation (NIV) improves the outcomes of patients hospitalized with severe COPD exacerbation, and NIV is recommended as the first-line therapy for these patients. Yet, several studies have demonstrated ...

Update to the study protocol for an implementation-effectiveness trial comparing two education strategies for improving the uptake of noninvasive ventilation in patients with severe COPD exacerbation (Mihaela Stefan, Penny Pekow, Jay Steingrub, et al.) All Scholarly Works (2021)

Background: There is strong evidence that noninvasive ventilation (NIV) improves the outcomes of patients hospitalized with severe COPD exacerbation, and NIV is recommended as the first-line therapy for these patients. Yet, several studies have demonstrated ...

Association Between mRNA Vaccination and COVID-19 Hospitalization and Disease Severity (Jay Steingrub) All Scholarly Works (2021)

Importance: A comprehensive understanding of the benefits of COVID-19 vaccination requires consideration of disease attenuation, determined as whether people who develop COVID-19 despite vaccination have lower disease severity than unvaccinated people. Objective: To evaluate the ...

Influenza vaccine acceptance and hesitancy among adults hospitalized with severe acute respiratory illnesses, United States 2019-2020 (Jay Steingrub) All Scholarly Works (2021)

Introduction: Understanding patient factors associated with not being vaccinated is essential for successful implementation of influenza vaccination programs. Methods: We enrolled adults hospitalized with severe acute respiratory illness at 10 United States (US) hospitals during ...

Sustained Effectiveness of Pfizer-BioNTech and Moderna Vaccines Against COVID-19 Associated Hospitalizations Among Adults - United States, March-July 2021 (Jay Steingrub and Ithan Peltan) All Scholarly Works (2021)

Real-world evaluations have demonstrated high effectiveness of vaccines against COVID-19-associated hospitalizations (1-4) measured shortly after vaccination; longer follow-up is needed to assess durability of protection. In an evaluation at 21 hospitals in 18 states, the ...

Adults Hospitalized with COVID-19 -United States, March-June and October-December 2020: Implications for the Potential Effects of COVID-19 (Jay Steingrub) All Scholarly Works (2021)

Background: Because of the increased risk for severe coronavirus disease 2019 (COVID-19), the Advisory Committee on Immunization Practices (ACIP) initially prioritized COVID-19 vaccination for persons in long-term care facilities (LTCF), persons aged ≥65 years, and ...

Effectiveness of Pfizer-BioNTech and Moderna Vaccines Against COVID-19 Among Hospitalized Adults Aged ≥65 Years - United States, January-March 2021 (Jay Steingrub, Lesley DeSouza, Lori-Ann Kozikowski, et al.) All Scholarly Works (2021)

Adults aged ≥65 years are at increased risk for severe outcomes from COVID-19 and were identified as a priority group to receive the first COVID-19 vaccines approved for use under an Emergency Use Authorization (EUA) ...

Influenza Vaccine Effectiveness for Prevention of Severe Influenza-Associated Illness among Adults in the United States, 2019-2020: A test-negative study (Jay Steingrub) All Scholarly Works (2021)

Background: Influenza vaccine effectiveness (VE) against a spectrum of severe disease, including critical illness and death, remains poorly characterized. Methods: We conducted a test-negative study in an intensive care unit (ICU) network at 10 United ...

Modeling the impacts of clinical influenza testing on influenza vaccine effectiveness estimates (Jay Steingrub) All Scholarly Works (2021)

Background: Test-negative design studies for evaluating influenza vaccine effectiveness (VE) enroll patients with acute respiratory infection. Enrollment typically occurs before influenza status is determined, resulting in over-enrollment of influenza-negative patients. With availability of rapid and ...

ICU Bed Utilization During the Coronavirus Disease 2019 Pandemic in a Multistate Analysis-March to June 2020 (Jay Steingrub) All Scholarly Works (2021)

Objectives: Given finite ICU bed capacity, knowledge of ICU bed utilization during the coronavirus disease 2019 pandemic is critical to ensure future strategies for resource allocation and utilization. We sought to examine ICU census trends ...

A scoring system derived from electronic health records to identify patients at high risk for noninvasive ventilation failure (Mihaela Stefan, Aruna Priya, Penny Pekow, et al.) All Scholarly Works (2021)

Objective: To develop and validate a clinical risk prediction score for noninvasive ventilation (NIV) failure defined as intubation after a trial of NIV in non-surgical patients. Design: Retrospective cohort study of a multihospital electronic health ...

Enabling a learning healthcare system with automated computer protocols that produce replicable and personalized clinician actions (Jay Steingrub) All Scholarly Works (2021)

Clinical decision-making is based on knowledge, expertise, and authority, with clinicians approving almost every intervention-the starting point for delivery of "All the right care, but only the right care," an unachieved healthcare quality improvement goal. ...

Symptoms and recovery among adult outpatients with and without COVID-19 at 11 healthcare facilities-July 2020, United States (Jay Steingrub) All Scholarly Works (2021)

Background: Symptoms of mild COVID-19 illness are non-specific and may persist for prolonged periods. Effects on quality of life of persistent poor physical or mental health associated with COVID-19 are not well understood. Methods: Adults ...

JAMA . 2020 Nov 9. doi: 10.1001/jama.2020.22240. Online ahead of print. Effect of Hydroxychloroquine on Clinical Status at 14 Days in Hospitalized Patients With COVID-19: A Randomized Clinical Trial (Jay Steingrub) All Scholarly Works (2020)

Importance: Data on the efficacy of hydroxychloroquine for the treatment of coronavirus disease 2019 (COVID-19) are needed. Objective: To determine whether hydroxychloroquine is an efficacious treatment for adults hospitalized with COVID-19. Design, setting, and participants: ...

Incorporating real-time influenza detection into the test-negative design for estimating influenza vaccine effectiveness: The real-time test-negative design (rtTND) (Jay Steingrub) All Scholarly Works (2020)

With rapid and accurate molecular influenza testing now widely available in clinical settings, influenza vaccine effectiveness (VE) studies can prospectively select participants for enrollment based on real-time results rather than enrolling all eligible patients regardless ...

Characteristics of Adult Outpatients and Inpatients with COVID-19 - 11 Academic Medical Centers, United States, March-May 2020 (Jay Steingrub) All Scholarly Works (2020)

Descriptions of coronavirus disease 2019 (COVID-19) in the United States have focused primarily on hospitalized patients. Reports documenting exposures to SARS-CoV-2, the virus that causes COVID-19, have generally been described within congregate settings, such as ...

Rationale and Design of ORCHID: A Randomized Placebo-Controlled Trial of Hydroxychloroquine for Adults Hospitalized With COVID-19 (Jay Steingrub) All Scholarly Works (2020)

The Outcomes Related to COVID-19 treated with Hydroxychloroquine among In-patients with symptomatic Disease (ORCHID) trial is a multicenter, blinded, randomized trial of hydroxychloroquine versus placebo for the treatment of adults hospitalized with COVID-19. This document ...

Protocol for Two-Arm Pragmatic Cluster Randomized Hybrid Implementation-Effectiveness Trial Comparing Two Education Strategies for Improving the Uptake of Noninvasive Ventilation in Patients With Severe COPD Exacerbation (Mihaela Stefan, Penny Pekow, Jay Steingrub, et al.) All Scholarly Works (2020)

Background: COPD is the fourth leading cause of death in the US, and COPD exacerbations result in approximately 700,000 hospitalizations annually. Patients with acute respiratory failure due to severe COPD exacerbation are treated with invasive ...

Association of Elevated Plasma Interleukin 18 Level With Increased Mortality in a Clinical Trial of Statin Treatment for Acute Respiratory Distress Syndrome (Lori-Ann Kozikowski, Lesley DeSouza and Jay Steingrub) All Scholarly Works (2019)

OBJECTIVE: A high plasma level of inflammasome mediator interleukin-18 was associated with mortality in observational acute respiratory distress syndrome cohorts. Statin exposure increases both inflammasome activation and lung injury in mouse models. We tested whether ...

A Multicenter Study of the Causes and Consequences of Optimistic Expectations About Prognosis by Surrogate Decision-Makers in ICUs (Jay Steingrub) All Scholarly Works (2019)

OBJECTIVES: Optimistic expectations about prognosis by surrogate decision-makers in ICUs are common, but there are few data about the causes and clinical consequences. Our objective was to determine the causes of optimistic expectations about prognosis ...

Clinician-Family Communication About Patients' Values and Preferences in Intensive Care Units (Jay Steingrub) All Scholarly Works (2019)

Importance: Little is known about whether clinicians and surrogate decision makers follow recommended strategies for shared decision making by incorporating intensive care unit (ICU) patients' values and preferences into treatment decisions. Objectives: To determine how ...

Prospective Assessment of the Feasibility of a Trial of Low-Tidal Volume Ventilation for Patients with Acute Respiratory Failure (Jay Steingrub and Mark Tidswell) All Scholarly Works (2019)

RATIONALE: Low-tidal volume ventilation (LTVV; 6 ml/kg) benefits patients with acute respiratory distress syndrome and may aid those with other causes of respiratory failure. Current early ventilation practices are poorly defined. OBJECTIVES: We observed patients ...

An analysis of homeless patients in the United States requiring ICU admission (Thomas Higgins, Mihaela Stefan, Tara Lagu, et al.) All Scholarly Works (2019)

PURPOSE: To assess how homelessness impacts mortality and length of stay (LOS) among select the intensive care unit (ICU) patients. METHODS: We used ICD-9 code V60.0 to identify homeless patients using the Premier Perspective Database ...

Prospective Assessment of the Feasibility of a Trial of Low Tidal Volume Ventilation for Patients with Acute Respiratory Failure (Jay Steingrub and Mark Tidswell) All Scholarly Works (2018)

RATIONALE: Low tidal volume ventilation (LTVV, 6 mL/kg) benefits patients with acute respiratory distress syndrome (ARDS) and may aid those with other causes of respiratory failure. Current early ventilation practices are poorly defined. OBJECTIVES: We ...

An analysis of homeless patients in the United States requiring ICU admission (Brian Nathanson, Mihaela Stefan, Tara Lagu, et al.) All Scholarly Works (2018)

PURPOSE: To assess how homelessness impacts mortality and length of stay (LOS) among select the intensive care unit (ICU) patients. METHODS: We used ICD-9 code V60.0 to identify homeless patients using the Premier Perspective Database ...