Real-world evaluations have demonstrated high effectiveness of vaccines against COVID-19-associated hospitalizations (1-4) measured shortly after vaccination; longer follow-up is needed to assess durability of protection. In an evaluation at 21 hospitals in 18 states, the duration of mRNA vaccine (Pfizer-BioNTech or Moderna) effectiveness (VE) against COVID-19-associated hospitalizations was assessed among adults aged ≥18 years. Among 3,089 hospitalized adults (including 1,194 COVID-19 case-patients and 1,895 non-COVID-19 control-patients), the median age was 59 years, 48.7% were female, and 21.1% had an immunocompromising condition. Overall, 141 (11.8%) case-patients and 988 (52.1%) controls were fully vaccinated (defined as receipt of the second dose of Pfizer-BioNTech or Moderna mRNA COVID-19 vaccines ≥14 days before illness onset), with a median interval of 65 days (range = 14-166 days) after receipt of second dose. VE against COVID-19-associated hospitalization during the full surveillance period was 86% (95% confidence interval [CI] = 82%-88%) overall and 90% (95% CI = 87%-92%) among adults without immunocompromising conditions. VE against COVID-19- associated hospitalization was 86% (95% CI = 82%-90%) 2-12 weeks and 84% (95% CI = 77%-90%) 13-24 weeks from receipt of the second vaccine dose, with no significant change between these periods (p = 0.854). Whole genome sequencing of 454 case-patient specimens found that 242 (53.3%) belonged to the B.1.1.7 (Alpha) lineage and 74 (16.3%) to the B.1.617.2 (Delta) lineage. Effectiveness of mRNA vaccines against COVID-19-associated hospitalization was sustained over a 24-week period, including among groups at higher risk for severe COVID-19; ongoing monitoring is needed as new SARS-CoV-2 variants emerge. To reduce their risk for hospitalization, all eligible persons should be offered COVID-19 vaccination.
Article
Sustained Effectiveness of Pfizer-BioNTech and Moderna Vaccines Against COVID-19 Associated Hospitalizations Among Adults - United States, March-July 2021
All Scholarly Works
Document Type
Article, Peer-reviewed
Publication Date
8-1-2021
Disciplines
Abstract
PMID
34437524
Citation Information
Tenforde MW, Self WH, Naioti EA, Ginde AA, Douin DJ, Olson SM, Talbot HK, Casey JD, Mohr NM, Zepeski A, Gaglani M, McNeal T, Ghamande S, Shapiro NI, Gibbs KW, Files DC, Hager DN, Shehu A, Prekker ME, Erickson HL, Gong MN, Mohamed A, Henning DJ, Steingrub JS, Peltan ID, Brown SM, Martin ET, Monto AS, Khan A, Hough CL, Busse LW, Ten Lohuis CC, Duggal A, Wilson JG, Gordon AJ, Qadir N, Chang SY, Mallow C, Rivas C, Babcock HM, Kwon JH, Exline MC, Halasa N, Chappell JD, Lauring AS, Grijalva CG, Rice TW, Jones ID, Stubblefield WB, Baughman A, Womack KN, Lindsell CJ, Hart KW, Zhu Y, Stephenson M, Schrag SJ, Kobayashi M, Verani JR, Patel MM; IVY Network Investigators; IVY Network. Sustained Effectiveness of Pfizer-BioNTech and Moderna Vaccines Against COVID-19 Associated Hospitalizations Among Adults - United States, March-July 2021. MMWR Morb Mortal Wkly Rep. 2021 Aug 27;70(34):1156-1162. doi: 10.15585/mmwr.mm7034e2.
Collaborators - Calhoun N, Murthy K, Herrick J, McKillop A, Hoffman E, Zayed M, Smith M, Settele N, Ettlinger J, Priest E, Thomas J, Arroliga A, Beeram M, Kindle R, Kozikowski L, De Souza L, Ouellette S, Thornton-Thompson S, Tyler P, Mehkri O, Ashok K, Gole S, King A, Poynter B, Stanley N, Hendrickson A, Maruggi E, Scharber T, Jorgensen J, Bowers R, King J, Aston V, Armbruster B, Rothman RE, Nair R, Chen JTT, Karow S, Robart E, Maldonado PN, Khan M, So P, Levitt J, Perez C, Visweswaran A, Roque J, Rivera A, Frankel T, Howell M, Friedel J, Goff J, Huynh D, Tozier M, Driver C, Carricato M, Foster A, Nassar P, Stout L, Sibenaller Z, Walter A, Mares J, Olson L, Clinansmith B, Rivas C, Gershengorn H, McSpadden EJ, Truscon R, Kaniclides A, Lara Thomas L, Bielak R, Valvano WD, Fong R, Fitzsimmons WJ, Blair C, Valesano A, Gilbert J, Crider CD, Steinbock KA, Paulson TC, Anderson LA, Kampe C, Johnson J, McHenry R, Blair M, Conway D, LaRose M, Landreth L, Hicks M, Parks L, Bongu J, McDonald D, Cass C, Seiler S, Park D, Hink T, Wallace M, Burnham CA, Arter OG.