Physical and questionnaire data were collected from 95 workstations at an open-plan office building in Michigan, US. The physical measurements encompassed thermal, lighting, and acoustic variables, furniture dimensions, and an assessment of potential exterior view. Occupants answered a detailed questionnaire concerning their environmental and job satisfaction, and aspects of well-being. These data were used to test, via mediated regression, a model linking the physical environment, through environmental satisfaction, to job satisfaction and other related measures. In particular, a significant link was demonstrated between overall environmental satisfaction and job satisfaction, mediated by satisfaction with management and with compensation. Analysis of physical data was limited to the lighting domain. Results confirmed the important role of window access at the desk in satisfaction with lighting, particularly through its effect on satisfaction with outside view.