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Article
Large Scale Nanoparticle Screening for Small Molecule Analysis in Laser Desorption Ionization Mass Spectrometry
Analytical Chemistry
  • Gargey B. Yagnik
  • Rebecca L. Hansen, Iowa State University
  • Andrew R. Korte, Iowa State University
  • Malinda D. Reichert, Iowa State University
  • Javier Vela, Iowa State University
  • Young-Jin Lee, Iowa State University
Document Type
Article
Publication Version
Published Version
Publication Date
9-20-2016
DOI
10.1021/acs.analchem.6b02732
Abstract

Nanoparticles (NPs) have been suggested as efficient matrixes for small molecule profiling and imaging by laser-desorption ionization mass spectrometry (LDI-MS), but so far there has been no systematic study comparing different NPs in the analysis of various classes of small molecules. Here, we present a large scale screening of 13 NPs for the analysis of two dozen small metabolite molecules. Many NPs showed much higher LDI efficiency than organic matrixes in positive mode and some NPs showed comparable efficiencies for selected analytes in negative mode. Our results suggest that a thermally driven desorption process is a key factor for metal oxide NPs, but chemical interactions are also very important, especially for other NPs. The screening results provide a useful guideline for the selection of NPs in the LDI-MS analysis of small molecules.

Comments

Reprinted with permission from Analytical Chemistry 88 (2016): 8926, doi:10.1021/acs.analchem.6b02732. Copyright 2016 American Chemical Society.

Copyright Owner
American Chemical Society
Language
en
File Format
application/pdf
Citation Information
Gargey B. Yagnik, Rebecca L. Hansen, Andrew R. Korte, Malinda D. Reichert, et al.. "Large Scale Nanoparticle Screening for Small Molecule Analysis in Laser Desorption Ionization Mass Spectrometry" Analytical Chemistry Vol. 88 (2016) p. 8926 - 8930
Available at: http://works.bepress.com/javier_vela-becerra/31/