Article
Total synthesis of complex heterocyclic natural products
Pure and Applied Chemistry
(2009)
Abstract
Total synthesis campaigns toward complex heterocyclic natural products are a
prime source of inspiration for the design and execution of complex cascade sequences,
powerful reactions, and efficient synthetic strategies. We highlight selected examples of such
innovations in the course of our total syntheses of diazonamide A, azaspiracid-1, thiostrepton,
2,2'-epi-cytoskyrin A and rugulosin, abyssomicin C, platensimycin, and uncialamycin.
Keywords
- antibiotics,
- antitumor agents,
- marine neurotoxins,
- natural products,
- total synthesis
Disciplines
Publication Date
2009
DOI
10.1351/pac200880040727
Publisher Statement
This article is from Pure and Applied Chemistry 80 (2009): 727, doi:10.1351/pac200880040727. Posted with permission.
Citation Information
K.C. Nicolaou and Jason Chen. "Total synthesis of complex heterocyclic natural products" Pure and Applied Chemistry Vol. 80 Iss. 4 (2009) p. 727 - 742 Available at: http://works.bepress.com/jason-shih-hao-chen/8/