Article
Synthesis and Biological Evaluation of Novel Cyclosporin A Analogues: Potential Soft Drugs for the Treatment of Autoimmune Diseases
Journal of Medicinal Chemistry
(2003)
Abstract
Cyclosporin A is effective in the treatment of asthma patients, but its chronic use is limited by toxicity. Novel cyclosporin A analogues were synthesized utilizing the olefin metathesis reaction and evaluated in a calcineurin A inhibition assay. The novel analogues demonstrated activity comparable to activity of the parent molecule and are potential soft drugs.
Disciplines
Publication Date
2003
DOI
10.1021/jm025595i
Publisher Statement
Reprinted (adapted) with permission from J. Med. Chem., 2003, 46 (5), pp 674–676. Copyright 2003 American Chemical Society.
Citation Information
Tsvetelina Lazarova, Jason Chen, Blake Hamann, Jane M. Kang, et al.. "Synthesis and Biological Evaluation of Novel Cyclosporin A Analogues: Potential Soft Drugs for the Treatment of Autoimmune Diseases" Journal of Medicinal Chemistry Vol. 46 Iss. 5 (2003) p. 674 - 676 Available at: http://works.bepress.com/jason-shih-hao-chen/10/