With respect to the issue of the future of Cusanus research, the paper seeks to motivate questions about the degree to which dominant concerns of modern philosophy exhibit an often unacknowledged relationship to those of Renaissance philosophy and theology. Although the author has no wish to “modernize” Nicholas of Cusa, he contends that Cusanus research may be uniquely capable of providing insights into the question of the extent to which dominant habits of modern philosophy are significantly constituted by major commitments of medieval and Renaissance philosophy and theology.