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Longitudinal Transcriptomic Dysregulation in the Peripheral Blood of Transgenic Huntington’s Disease Monkeys
BMC Neuroscience (2013)
  • Jannet Kocerha, Georgia Southern University
  • Yuhong Liu
  • David Willoughby
  • Kumaravel Chidamparam
  • Joseph Benito
  • Kate Nelson
  • Yan Xu
  • Tim Chi
  • Heidi Engelhardt
  • Sean Moran
  • Shang-Hsun Yang
  • Shi-Hua Li
  • Xiao-Jiang Li
  • Katherine Larkin
  • Adam Neumann
  • Heather Banta
  • Jinjing Yang, Emory University
  • Anthony W. S. Chan, Emory University

Background: Huntington’s Disease (HD) is a progressive neurodegenerative disorder caused by an expansion in the polyglutamine (polyQ) region of the Huntingtin (HTT) gene. The clinical features of HD are characterized by cognitive, psychological, and motor deficits. Molecular instability, a core component in neurological disease progression, can be comprehensively evaluated through longitudinal transcriptomic profiling. Development of animal models amenable to longitudinal examination enables distinct disease-associated mechanisms to be identified.

Results: Here we report the first longitudinal study of transgenic monkeys with genomic integration of various lengths of the human HTT gene and a range of polyQ repeats. With this unique group of transgenic HD nonhuman primates (HD monkeys), we profiled over 47,000 transcripts from peripheral blood collected over a 2 year timespan from HD monkeys and age-matched wild-type control monkeys.

Conclusions: Messenger RNAs with expression patterns which diverged with disease progression in the HD monkeys considerably facilitated our search for transcripts with diagnostic or therapeutic potential in the blood of human HD patients, opening up a new avenue for clinical investigation.

  • Transcriptome,
  • Huntington’s Disease,
  • Longitudinal,
  • Monkeys,
  • Blood,
  • mRNA
Publication Date
August, 2013
Publisher Statement
© 2013 Kocerha et al.; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver applies to the data made available in this article, unless otherwise stated. Article originally published and obtained from BMC Neuroscience.
Citation Information
Jannet Kocerha, Yuhong Liu, David Willoughby, Kumaravel Chidamparam, Joseph Benito, Kate Nelson, Yan Xu, Tim Chi, Heidi Engelhardt, Sean Moran, Shang-Hsun Yang, Shi-Hua Li, Xiao-Jiang Li, Katherine Larkin, Adam Neumann, Heather Banta, Jinjing Yang, and Anthony W. S. Chan. "Longitudinal Transcriptomic Dysregulation in the Peripheral Blood of Transgenic Huntington’s Disease Monkeys" BMC Neuroscience 14.1 (2013): 88.
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