Skip to main content
Article
Invited Review: Heat Shock Proteins and Exercise: A Primer
Applied Physiology, Nutrition, and Metabolism (2008)
  • Earl G. Noble, The University of Western Ontario
  • Kevin J. Milne, The University of Western Ontario
  • C.W. James Melling, The University of Western Ontario
Abstract
Heat shock proteins (HSPs) are, in general, prosurvival molecules within the cellular environment, and the overexpression of even just 1 family of HSPs can lead to protection against and improvements after a variety of stressors. Not surprisingly, a fertile area of study has grown out of effors to exploit the innate biologic behaviour of HSPs. Exercise, because of the inherent physiologic stresses associated with it, is but 1 stimulus that can result in a robust increase in various HSPs in several tissues, not the least of which happen to be the heart and skeletal muscle. The purpose of this review is to introduce the reader to the major HSP families, the control of their expression, and some of their biologic functions, specifically with respect to the influence of exercise. Moreover, as the first in a series of reviews from a common symposium, we will briefly introduce the concepts presented by the other authors, which include the effects of different exercise paradigms on skeletal muscle HSPs in the adult and aged systems, HSPs as regulators of inflammation, and the ion channel stabilizing effects of HSPs.
Keywords
  • HSF,
  • stress response,
  • skeletal muscle,
  • cardioprotection,
  • signaling,
  • sex differences
Publication Date
2008
Citation Information
Earl G. Noble, Kevin J. Milne and C.W. James Melling. "Invited Review: Heat Shock Proteins and Exercise: A Primer" Applied Physiology, Nutrition, and Metabolism Vol. 33 Iss. 5 (2008)
Available at: http://works.bepress.com/jamie_melling/4/