Beekeepers and honey bee veterinarians have an important role to play in ensuring the health of bees and protecting the honey bee industry. Like other social organisms, honey bees are at risk for pathogen transmission through numerous routes, and co‐infections with multiple pathogens are not uncommon. Disease management in honey bees requires a combination of best management practices that keep the bees healthy and vigorous to enhance disease resistance and biosecurity to reduce disease exposure. Knowledge and implementation of best management practices with an emphasis on good biosecurity is a beekeeper's best defense in protecting the health and vitality of their honey bee colonies. Veterinarians working in honey bee medicine have the opportunity to provide valuable professional services to clients related to biosecurity and disease prevention and management.