Article
Characterization of Early Pathogenic Effects after Experimental Infection of Calves with Bovine Immunodeficiency-Like Virus
Journal of Virology
Document Type
Article
Disciplines
Publication Version
Published Version
Publication Date
2-1-1992
Abstract
The early pathogenic effects of bovine immunodeficiency-like virus (BIV) were studied in calves experimentally inoculated with BIV. All animals inoculated with BIV R29-infected cells seroconverted by 6 weeks postinoculation, and BIV was recoverable from each animal at 2 weeks postinoculation. However, levels of BIV replication in vivo appeared to be low. In situ hybridization studies indicated that during peak periods of viral replication in vivo, less than 0.03% of peripheral blood mononuclear cells were expressing detectable levels of viral RNA. Moreover, the levels of viral RNA in these cells in vivo were less than 1/10 the levels observed in persistently infected cells in vitro. BIV-inoculated calves had significantly higher numbers of circulating lymphocytes, and follicular hyperplasia was observed in lymph nodes, hemal nodes, and spleen. The histopathological changes observed in BIV-infected calves were similar to changes found early after infection with the immunosuppressive lentiviruses, including human immunodeficiency virus type 1.
Rights
Works produced by employees of the U.S. Government as part of their official duties are not copyrighted within the U.S. The content of this document is not copyrighted.
Language
en
File Format
application/pdf
Citation Information
Susan Long Carpenter, Lyle D. Miller, Soren Alexandersen, Cecelia Anne Whetstone, et al.. "Characterization of Early Pathogenic Effects after Experimental Infection of Calves with Bovine Immunodeficiency-Like Virus" Journal of Virology Vol. 66 Iss. 2 (1992) p. 1074 - 1083 Available at: http://works.bepress.com/james_roth/15/
This article is from Journal of Virology 66 (1992): 1074.