Meta-Analysis of Quantitative Trait Association and Mapping Studies using Parametric and Non-Parametric ModelsJournal of Biometrics & Biostatistics
Publication VersionPublished Version
AbstractMeta-analysis is an important method for integration of information from multiple studies. In quantitative trait association and mapping experiments, combining results from several studies allows greater statistical power for detection of causal loci and more precise estimation of their effects, and thus can yield stronger conclusions than individual studies. Various meta-analysis methods have been proposed for synthesizing information from multiple candidate gene studies and QTL mapping experiments, but there are several questions and challenges associated with these methods. For example, meta-analytic fixed-effect models assume homogeneity of outcomes from individual studies, which may not always be true. Whereas random-effect models takes into account the heterogeneity among studies they typically assume a normal distribution of study-specific outcomes. However in reality, the observed distribution pattern tends to be multi-modal, suggesting a mixture whose underlying components are not directly observable. In this paper, we examine several existing parametric meta-analysis methods, and propose the use of a non-parametric model with a Dirichlet process prior (DPP), which relaxes the normality assumptions about study- specific outcomes. With a DPP model, the posterior distribution of outcomes is discrete, reflecting a clustering property that may have biological implications. Features of these methods were illustrated and compared using both simulation data and real QTL data extracted from the Animal QTLdb (http://www.animalgenome.org/cgi-bin/QTLdb/index). The meta analysis of reported average daily body weight gain (ADG) QTL suggested that there could be from six to eight distinct ADG QTL on swine chromosome 1.
RightsThis is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Copyright OwnerXiao-Lin Wu, et al.
Citation InformationXiao-Lin Wu, Daniel Gianola, Zhi-Liang Hu and James M Reecy. "Meta-Analysis of Quantitative Trait Association and Mapping Studies using Parametric and Non-Parametric Models" Journal of Biometrics & Biostatistics Vol. S1 (2011) p. 1 - 9
Available at: http://works.bepress.com/james_reecy/55/