Unpublished Paper
Angus Dwarfism: The Short Story about ISU’s Discovery of a Causal Mutation for Dwarfism in American Angus
Animal Industry Report
Extension Number
ASL R2190
Publication Date
2007
Disciplines
Topic
Beef
Summary and Implications
Angus dwarfism has been localized to bovine chromosome 6 (BTA6) by linkage mapping. Four positional candidate genes suspected to alter bone development have been identified and are under analysis. A causative mutation was found in the PRKG2 gene. Subsequently, a genetic test was developed so that Angus breeders may select against dwarfism. This test successfully predicted which calves were dwarves with 100% accuracy in a breeding experiment recently concluded at Iowa State. Preliminary data in cell culture indicates that the mutation discovered changes the function of the PRKG2 gene, strongly suggesting it is the causative mutation in American Angus.
Copyright Holder
Iowa State University
Copyright Date
2007
DOI
https://doi.org/10.31274/ans_air-180814-418
Language
en
Citation Information
James Koltes, Liviu R. Totir, Bishnu P. Mishra, Michael Georges, et al.. "Angus Dwarfism: The Short Story about ISU’s Discovery of a Causal Mutation for Dwarfism in American Angus" (2007) Available at: http://works.bepress.com/james_reecy/14/