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Article
Neurotoxicosis associated with the use of hexachlorophene in a cat.
Journal of the American Veterinary Medical Association (1987)
  • James P Thompson, University of Florida
  • D. F. Senior
  • D. M. Pinson
  • K. A. Moriello
Abstract
Two weeks after daily topical application of hexachlorophene, a 4-week-old female kitten developed cardiovascular collapse, corneal ulcers, trembling, lethargy, and weakness. The kitten was euthanatized. At necropsy, the tissues appeared macroscopically normal; however, microscopic examination of tissue specimens indicated status spongiosis, astrocytosis, and microgliosis of the cerebral and cerebellar white matter and corticospinal tracts. Neuronal cell bodies forming the affected white matter were intact, indicating that demyelination may have been the cause of the lesions. The neurologic lesions were considered compatible with those of hexachlorophene-induced toxicosis.
Disciplines
Publication Date
1987
Citation Information
James P Thompson, D. F. Senior, D. M. Pinson and K. A. Moriello. "Neurotoxicosis associated with the use of hexachlorophene in a cat." Journal of the American Veterinary Medical Association Vol. 190 Iss. 10 (1987)
Available at: http://works.bepress.com/james_p_thompson/33/