Pathology of experimental infection with Brugia malayi in ferrets: comparison with occult filariasis in man.Acta Tropica (1984)
AbstractFerrets experimentally infected with Brugia malayi (subperiodic strain) developed eosinophilia at patency and usually became amicrofilaremic. Ferrets necropsied within 3 months after becoming amicrofilaremic had granulomas and focal reactions to degenerating microfilariae in their livers, lungs and lymph nodes essentially identical to those of tropical eosinophilia. Four of 7 ferrets that received multiple inoculations of larvae, developed edema of the inoculated paw and leg after becoming amicrofilaremic and 6 of these 7 ferrets had granulomatous lymphangitis and lymphadenitis of inoculated limbs but not the lesions of lung and liver characteristic of occult infection.
Citation InformationR. B. Crandall, James P Thompson, D. H. Connor, P. B. McGreevy, et al.. "Pathology of experimental infection with Brugia malayi in ferrets: comparison with occult filariasis in man." Acta Tropica Vol. 41 Iss. 4 (1984)
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