Skip to main content
Article
Effect of nicotine on saccadic eye movement latencies in non-smokers
Human Psychopharmacology: Clinical and Experimental
  • Alison C Bowling, Southern Cross University
  • James F Donnelly, Southern Cross University
Document Type
Article
Publication Date
7-1-2010
Peer Reviewed
Peer-Reviewed
Abstract
Objective Recently, saccadic eye movement tasks have been used to assess the effects of nicotine on higher cognitive processes, including inhibitory control. Saccadic task switching methods suggest that there is prolonged inhibition of the saccadic eye movement system following antisaccade trials. The objective of this research was to examine effects of nicotine on inhibition using saccadic task switching paradigms. Methods Nicotine and placebo lozenges were administered on separate days to 40 non-smokers who performed prosaccade and antisaccade tasks. In addition, participants performed a series of trials in which prosaccade and antisaccade tasks were switched. Eye movement latencies were recorded. Results Participants responded significantly faster for the nicotine condition than for the placebo condition. A switch benefit was observed for only placebo antisaccade trials, in that latencies of repetition trials were significantly longer than those of switch trials. In addition, an analysis of the repetition trials showed an interaction between saccade type and sequence position for the placebo condition, but not the nicotine condition. Conclusion Inhibition persists after antisaccade trials in a switching paradigm, but that the duration of this inhibition is reduced by nicotine.
Citation Information

Bowling, AC & Donnelly, JF 2010, 'Effect of nicotine on saccadic eye movement latencies in non-smokers', Human Psychopharmacology: Clinical and Experimental, vol. 25, no. 5, pp. 410-418.

The definitive version is available at www3.interscience.wiley.com, at http://dx.doi.org/10.1002/hup.1134