Skip to main content
Article
Involvement of dopamine D2 receptor in complex maze learning and acetylcholine release in ventral hippocampus of rats
Neuroscience
  • H. Umegaki
  • James R. Munoz, Nova Southeastern University
  • R.C. Meyer
  • E.L. Spangler
  • J. Yoshimura
  • H. Ikari
  • A.I. Iguchi
  • D.K. DeSimoni
Document Type
Article
Publication Date
1-1-2001
Keywords
  • memory; quinpirole; raclopride; eticlopride; microdialysis
Disciplines
Peer Reviewed
1
Abstract
In the current study we focus on the involvement of dopamine D2 receptors in the ventral hippocampus in memory performance and acetylcholine release. Using the aversively motivated 14-unit T-maze (Stone maze) the injection of raclopride, a D2 receptor antagonist, into the ventral hippocampus (8 μg/kg) was found to impair memory performance. Co-injection of quinpirole, a D2 receptor agonist (8 μg/kg), overcame the impairment in performance. Microdialysis study revealed that quinpirole infusion (10–500 μM) into the ventral hippocampus stimulated acetylcholine release in a dose-dependent manner, and systemic injection of quinpirole (0.5 mg/kg, i.p.) also stimulated acetylcholine release in the ventral hippocampus. Infusion of eticlopride, another D2receptor antagonist, into the ventral hippocampus suppressed acetylcholine release in the hippocampus induced by systemic injection of quinpirole. Taken together, we suggest that D2 receptors in the ventral hippocampus are involved in memory performance, possibly through the regulation of acetylcholine.
DOI
http://dx.doi.org/10.1016/S0306-4522(00)00542-X
Citation Information
H. Umegaki, James R. Munoz, R.C. Meyer, E.L. Spangler, et al.. "Involvement of dopamine D2 receptor in complex maze learning and acetylcholine release in ventral hippocampus of rats" Neuroscience Vol. 103 Iss. 1 (2001) p. 27 - 33 ISSN: 0306-4522
Available at: http://works.bepress.com/james-munoz/28/