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Article
Portable capillary liquid chromatography for pharmaceutical and illicit drug analysis
Journal of Separation Science
(2020)
Abstract
A newly developed portable capillary liquid chromatograph was investigated for the separation of various pharmaceutical and illicit drug compounds. The system consists of two high‐pressure syringe pumps capable of delivering capillary‐scale flow rates at pressures up to 10 000 psi. Capillary liquid chromatography columns packed with sub‐2 μm particles are housed in cartridges that can be inserted into the system and easily connected through high‐pressure fluidic contact points by simply applying a specific, predetermined torque rather than using standard fittings and less precise sealing protocols. Several over‐the‐counter analgesic drug separations are demonstrated, along with a simple online measurement of tablet dissolution. Twenty illicit drug compounds were also separated across six targeted drug panels. The results described in this study demonstrate the capability of this compact liquid chromatography instrument to address several important drug‐related applications while simplifying system operation, and greatly reducing solvent usage and waste generation essential for onsite analysis.
Disciplines
Publication Date
January 20, 2020
DOI
10.1002/JSSC.201901276
Citation Information
Samuel W. Foster, Xiaofeng Xie, Michelle Pham, Paul A. Peaden, et al.. "Portable capillary liquid chromatography for pharmaceutical and illicit drug analysis" Journal of Separation Science Vol. 43 Iss. 9-10 (2020) p. 1623 - 1627 Available at: http://works.bepress.com/james-grinias/17/