The signal in channels with high-speed designs is attenuated by channel loss, inter-symbol interference, jitter, noise and crosstalk. The main way to recover the signal is by using equalizations, such as Feed-Forward Equalizer, Continuous Time-Linear Equalizer and Decision Feedback Equalizer. One of the important problems of high-speed design and channel simulations is to develop fast optimization algorithms for choosing best tap coefficients for equalizers. Equalization of multi-level signal is more complicated and optimization algorithms require specific approach. The paper proposes a new efficient optimization of Decision Feedback Equalization (DFE) for binary and multi-level signals. Mathematical formulation of the optimization is given. Simulations were conducted for channels with different characteristics and comparison results are shown.