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Article
Experimental sleep fragmentation impairs attentional set-shifting in a rodent model of obstructive sleep apnea
Sleep
  • J.G. McCoy
  • Jaime L. Tartar, Nova Southeastern University
  • A.C. Bebis
  • M.M. Thakkar
  • J.T. McKenna
  • M.G. Baxter
  • R.W. McCarley
  • J. McGaughy
  • R.E. Strecker
Document Type
Article
Publication Date
1-1-2007
Keywords
  • sleep deprivation,
  • water maze,
  • hippocampus,
  • sleepiness
Disciplines
Peer Reviewed
1
Abstract
Sleep fragmentation is a common symptom in sleep disorders and other medical complaints resulting in excessive daytime sleepiness. The present study seeks to explore the effects of sleep fragmentation on learning and memory in a spatial reference memory task and a spatial working memory task. Fisher/Brown Norway rats lived in custom treadmills designed to induce locomotor activity every 2 minutes throughout a 24 hour period. Separate rats were either on a treadmill schedule that allowed for consolidated sleep or experienced no locomotor activation. Rats were tested in one of two water maze based tests of learning and memory immediately following 24 hours of sleep interruption (SI). Rats tested in a spatial reference memory task (8 massed acquisition trials) with a 24 hour follow-up probe trial to assess memory retention showed no differences in acquisition performance but were impaired on the 24 hour retention of the platform location. In contrast, the performance of rats tested in a spatial working memory task (delayed matching to position task) was not impaired. Therefore, sleepiness induced by SI effectively impairs the recall of spatial reference memories but does not impair spatial reference memory acquisition or spatial working memory in Fischer-Norway rats.
DOI
10.1111/j.1365-2869.2008.00714.x
Citation Information
J.G. McCoy, Jaime L. Tartar, A.C. Bebis, M.M. Thakkar, et al.. "Experimental sleep fragmentation impairs attentional set-shifting in a rodent model of obstructive sleep apnea" Sleep Vol. 30 Iss. 1 (2007) p. 52 - 60 ISSN: 0161-8105
Available at: http://works.bepress.com/jaime-tartar/36/