This paper presents a novel approximation-based event-triggered control of multi-input multi-output uncertain nonlinear continuous-time systems in affine form. The controller is approximated using a linearly parameterized neural network (NN) in the context of event-based sampling. After revisiting the NN approximation property in the context of event-based sampling, an event-triggered condition is proposed using the Lyapunov technique to reduce the network resource utilization and to generate the required number of events for the NN approximation. In addition, a novel weight update law for aperiodic tuning of the NN weights at triggered instants is proposed to relax the knowledge of complete system dynamics and to reduce the computation when compared with the traditional NN-based control. Nonetheless, a nonzero positive lower bound for the inter-event times is guaranteed to avoid the accumulation of events or Zeno behavior. For analyzing the stability, the event-triggered system is modeled as a nonlinear impulsive dynamical system and the Lyapunov technique is used to show local ultimate boundedness of all signals. Furthermore, in order to overcome the unnecessary triggered events when the system states are inside the ultimate bound, a dead-zone operator is used to reset the event-trigger errors to zero. Finally, the analytical design is substantiated with numerical results.