This paper presents a novel radio-frequency identification (RFID)-based smart freezer using a new inventory-management scheme for extremely low temperature environments. The proposed solution utilizes backpressure inventory control, systematic selection of antenna configuration, and antenna power control. The proposed distributed-inventory-control (DIC) scheme dictates the amount of items transferred through the supply chain. when a high item visibility is ensured, the control scheme maintains the desired level of inventory at each supply-chain echelon. The performance of the DIC scheme is guaranteed using a Lyapunov-based analysis. The proposed RFID antenna-configuration design methodology coupled with locally asymptotically stable distributed power control ensures a 99% read rate of items while minimizing the required number of RFID antennas in the confined cold chain environments with non-RF-friendly materials. The proposed RFID-based smart-freezer performance is verified through simulations of supply chain and experiments on an industrial freezer testbed operating at -100degF.