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Article
MyoD-Positive Epiblast Cells Regulate Skeletal Muscle Differentiation in the Embryo
The Journal of Cell Biology
  • Jacquelyn Gerhart, Philadelphia College of Osteopathic Medicine
  • Justin Elder, Philadelphia College of Osteopathic Medicine
  • Christine Neely
  • Jared Schure
  • Tage Kvist, Philadelphia College of Osteopathic Medicine
  • Karen Knudsen
  • Mindy George-Weinstein, Philadelphia College of Osteopathic Medicine
Document Type
Article
Publication Date
10-23-2006
Abstract
MyoD mRNA is expressed in a subpopulation of cells within the embryonic epiblast. Most of these cells are incorporated into somites and synthesize Noggin. Ablation of MyoD-positive cells in the epiblast subsequently results in the herniation of organs through the ventral body wall, a decrease in the expression of Noggin, MyoD, Myf5, and myosin in the somites and limbs, and an increase in Pax-3-positive myogenic precursors. The addition of Noggin lateral to the somites compensates for the loss of MyoD-positive epiblast cells. Skeletal muscle stem cells that arise in the epiblast are utilized in the somites to promote muscle differentiation by serving as a source of Noggin.
PubMed ID
17060497
Comments

This article was published in Journal of Cell Biology, Volume 175, Issue 2, October 23, 2006, Pages 283-292.

The published version is available at http://dx.doi.org/10.1083/jcb.200605037

Copyright © 2006 The Rockefeller University Press

Citation Information
Jacquelyn Gerhart, Justin Elder, Christine Neely, Jared Schure, et al.. "MyoD-Positive Epiblast Cells Regulate Skeletal Muscle Differentiation in the Embryo" The Journal of Cell Biology Vol. 175 Iss. 2 (2006) p. 283 - 292
Available at: http://works.bepress.com/jacquelyn-gerhart/9/