MyoD-Positive Epiblast Cells Regulate Skeletal Muscle Differentiation in the EmbryoThe Journal of Cell Biology
AbstractMyoD mRNA is expressed in a subpopulation of cells within the embryonic epiblast. Most of these cells are incorporated into somites and synthesize Noggin. Ablation of MyoD-positive cells in the epiblast subsequently results in the herniation of organs through the ventral body wall, a decrease in the expression of Noggin, MyoD, Myf5, and myosin in the somites and limbs, and an increase in Pax-3-positive myogenic precursors. The addition of Noggin lateral to the somites compensates for the loss of MyoD-positive epiblast cells. Skeletal muscle stem cells that arise in the epiblast are utilized in the somites to promote muscle differentiation by serving as a source of Noggin.
Citation InformationJacquelyn Gerhart, Justin Elder, Christine Neely, Jared Schure, et al.. "MyoD-Positive Epiblast Cells Regulate Skeletal Muscle Differentiation in the Embryo" The Journal of Cell Biology Vol. 175 Iss. 2 (2006) p. 283 - 292
Available at: http://works.bepress.com/jacquelyn-gerhart/9/