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Hepatocyte Growth Factor/Scatter Factor Promotes a Switch From E- to N-cadherin in Chick Embryo Epiblast Cells.
Experimental Cell Research
  • Steven M DeLuca
  • Jacquelyn Gerhart, Philadelphia College of Osteopathic Medicine
  • Eric Cochran
  • Eileen Simak
  • Jennifer Blitz
  • Michelle Mattiacci-Paessler
  • Karen Knudsen
  • Mindy George-Weinstein, Philadelphia College of Osteopathic Medicine
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Epiblast cells downregulate E-cadherin and upregulate N-cadherin as they ingress through the primitive streak and when placed in culture. The factors that promote the alteration in cadherin expression during gastrulation are unknown. The effects of hepatocyte growth factor/scatter factor (HGF/SF) on cadherin expression were tested in cultures of prestreak epiblast cells. HGF/SF decreased the expression of E-cadherin and increased the percentage of cells with N-cadherin and sarcomeric myosin. Cells with N-cadherin but not E-cadherin differentiated into skeletal muscle. HGF/SF also stimulated proliferation and the formation of cellular aggregates. Sensitivity to HGF/SF in vitro depended on the original position of cells within the epiblast. More cells from the lateral epiblast switched cadherins and proliferated in response to HGF/SF than medial epiblast cells. HGF/SF may affect gastrulation by altering cadherin expression, modulating cell adhesion, and stimulating proliferation within the epiblast.
PubMed ID

This article was published in Experimental Cell Research, Volume 251, Issue 1, Pages 3-15.

The published version is available at

Copyright © 1999.

Citation Information
Steven M DeLuca, Jacquelyn Gerhart, Eric Cochran, Eileen Simak, et al.. "Hepatocyte Growth Factor/Scatter Factor Promotes a Switch From E- to N-cadherin in Chick Embryo Epiblast Cells." Experimental Cell Research Vol. 251 Iss. 1 (1999) p. 3 - 15
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