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Article
Myo/Nog cells in normal, wounded and tumor-bearing skin
Experimental dermatology
  • Jacquelyn Gerhart, Philadelphia College of Osteopathic Medicine
  • C. Hayes
  • V. Scheinfeld
  • M. Chernick
  • Mindy George-Weinstein, Philadelphia College of Osteopathic Medicine
  • S. Gilmour
Document Type
Article
Publication Date
1-1-2012
Disciplines
Abstract
Murine and human skin were examined for the presence of Myo/Nog cells that were originally discovered in the chick embryo by their expression of MyoD mRNA, noggin and the G8 antigen. Myo/Nog cells are the primary source of noggin in telogen hair follicles. They are scarce within the interfollicular dermis and absent in the epidermis. Within 24 h following epidermal abrasion, Myo/Nog cells increase in number in the follicles and appear in the wound. Myo/Nog cells are also recruited to the stroma of tumors formed from v-Ras-transformed keratinocytes (Ker/Ras). Human squamous cell carcinomas and malignant melanomas contain significantly more Myo/Nog cells than basal cell carcinomas. Myo/Nog cells are distinct from macrophages, granulocytes and cells expressing alpha smooth muscle actin in the tumor stroma. Myo/Nog cells may be modulators of skin homoeostasis and wound healing, and potential diagnostic and therapeutic targets in skin cancer.
Comments

This article was published in Experimental dermatology, Volume 21, Issue 6, Pages 466-468.

The published version is available at http://dx.doi.org/10.1111/j.1600-0625.2012.01503.

Copyright © 2012 Wiley.

Citation Information
Jacquelyn Gerhart, C. Hayes, V. Scheinfeld, M. Chernick, et al.. "Myo/Nog cells in normal, wounded and tumor-bearing skin" Experimental dermatology Vol. 21 Iss. 6 (2012) p. 466 - 468
Available at: http://works.bepress.com/jacquelyn-gerhart/19/