Myo/Nog cells in normal, wounded and tumor-bearing skinExperimental dermatology
AbstractMurine and human skin were examined for the presence of Myo/Nog cells that were originally discovered in the chick embryo by their expression of MyoD mRNA, noggin and the G8 antigen. Myo/Nog cells are the primary source of noggin in telogen hair follicles. They are scarce within the interfollicular dermis and absent in the epidermis. Within 24 h following epidermal abrasion, Myo/Nog cells increase in number in the follicles and appear in the wound. Myo/Nog cells are also recruited to the stroma of tumors formed from v-Ras-transformed keratinocytes (Ker/Ras). Human squamous cell carcinomas and malignant melanomas contain significantly more Myo/Nog cells than basal cell carcinomas. Myo/Nog cells are distinct from macrophages, granulocytes and cells expressing alpha smooth muscle actin in the tumor stroma. Myo/Nog cells may be modulators of skin homoeostasis and wound healing, and potential diagnostic and therapeutic targets in skin cancer.
Citation InformationJacquelyn Gerhart, C. Hayes, V. Scheinfeld, M. Chernick, et al.. "Myo/Nog cells in normal, wounded and tumor-bearing skin" Experimental dermatology Vol. 21 Iss. 6 (2012) p. 466 - 468
Available at: http://works.bepress.com/jacquelyn-gerhart/19/