Perinatal mood and anxiety disorders (PMADs; a spectrum of emotional and psychological complications that affect expectant or new parents) are among the most common mental health issues affecting working age adults across the globe. Although most people who experience PMADs self-identity as women, PMADs can affect people of all genders. Untreated PMADs have the potential to impact long-term mental and physical health, the health and development of their children, and are among the leading causes of morbidity and mortality worldwide. The negative psychosocial outcomes associated with PMADs, coupled with their significant economic losses, represent significant public health concerns that warrant broader attention and support. In this chapter, we summarize PMADs and one such source of support: employment. We explore how organizational policies, management practices, and inclusive, non-stigmatizing workplace climates can reduce the consequences of PMADs and support workers in seeking and receiving treatment.