This is the inaugural symposium of the Journal of Legal Medicine hosted by the Center for Law Health and Society at Georgia State University College of Law focusing on legal and policy strategies to address spiraling prescription drug costs in the United States. The symposium opens with a keynote address by Michelle Mello, a co-author of the groundbreaking report, Making Medicines Affordable: A National Imperative, published by the National Academies of Sciences, Engineering and Medicine in 2017. The keynote address will frame the problem and landscape of legal and policy challenges of unaffordable prescription drugs and therapies. The symposium will then proceed to two sessions featuring state, federal, and academic experts discussing legal strategies to address pharmaceutical prices organized along two themes: (1) state policies to combat drug pricing, such as price transparency, drug importation, or anti-price gouging laws as well as legal challenges to these measures; (2) competition and innovation laws and policies in the market for prescription drugs, including antitrust law, FDA oversight, and patent law. Following the two open sessions, the symposium will adjourn to a session (closed to the public) where the invited speakers will discuss legal and policy strategies and identify priority areas for further research, advocacy, or policy development to contain rising prescription drug prices.